Tsultrim Gyamtso was born in Dzuktrun, Darlag County, Golok. When he was seven years old, his father died in a battle. After her husband passed away, Tsultrim Gyamtso's mother became distraught and had a nervous breakdown, and was unable to look after her son. When Khenpo Kunzang Gyaltsen learned of this situation, he enrolled Tsultrim Gyamtso in this school.